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Cascade Pharmaceuticals is a clinical-stage biopharmaceutical company established on December 26, 2017. Focused on addressing unmet medical needs in metabolic diseases and inflammation, the company specializes in the discovery, development, and commercialization of innovative drugs targeting nuclear receptors and G protein-coupled receptors (GPCRs). Guided by its mission, “Curing diseases, enabling healthier lives,” Cascade strives to be a global leader in next-generation drug development. With over 30 years of expertise in innovative drug development, Cascade is a pioneer in utilizing protein crystal structures for drug design. Its core team possesses end-to-end experience in pharmaceutical R&D and commercialization. Backed by a strong culture of innovation, the company has established a comprehensive preclinical research platform, including SPF-grade animal facilities, drug design and synthesis systems, and platforms for drug metabolism, pharmacology, and efficacy evaluation, etc.

Cascade Pharmaceuticals is a clinical-stage biopharmaceutical company established on December 26, 2017. Focused on addressing unmet medical needs in metabolic diseases and inflammation, the company specializes in the discovery, development, and commercialization of innovative drugs targeting nuclear receptors and G protein-coupled receptors (GPCRs). Guided by its mission, “Curing diseases, enabling healthier lives,” Cascade strives to be a global leader in next-generation drug development. With over 30 years of expertise in innovative drug development, Cascade is a pioneer in utilizing protein crystal structures for drug design. Its core team possesses end-to-end experience in pharmaceutical R&D and commercialization. Backed by a strong culture of innovation, the company has established a comprehensive preclinical research platform, including SPF-grade animal facilities, drug design and synthesis systems, and platforms for drug metabolism, pharmacology, and efficacy evaluation, etc.

Research and development

Research & Development

  • Pipeline

    Cascade Pharmaceuticals emphasizes originality and focuses on differentiated innovation in drug development. The company is actively advancing multiple drug candidates targeting over 10 distinct targets. By adhering to first principles of drug development and aligning with the body's natural physiological rhythms, the team has successfully developed Linafexor, a first-in-class FXR agonist, and Thybetaxor, a potential best-in-class thyroid hormone receptor β (THRβ) agonist.

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  • Technology Platform

    Cascade has built a full-cycle platform for precision small molecule drug R&D. The platform covers drug design, molecular and cellular analysis, efficacy testing, metabolism studies, and toxicology evaluation. Using this system, Cascade has developed patent-protected small molecule drugs, now advancing to clinical trials.The comprehensive technology platform is the catalyst for rapid iteration of innovative product development.

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